{"id":2584,"date":"2022-10-11T15:40:35","date_gmt":"2022-10-11T15:40:35","guid":{"rendered":"https:\/\/mtortho.com\/?page_id=2584"},"modified":"2022-10-12T15:15:19","modified_gmt":"2022-10-12T15:15:19","slug":"bone-blast-technology-evolution","status":"publish","type":"page","link":"https:\/\/mtortho.com\/en\/bone-blast-technology-evolution\/","title":{"rendered":"Bone Blast Technology Evolution"},"content":{"rendered":"<p><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-1 fusion-flex-container hundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"background-color: rgba(255,255,255,0);background-position: center center;background-repeat: no-repeat;border-width: 0px 0px 0px 0px;border-color:rgba(97,158,133,0);border-style:solid;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start\" style=\"width:104% !important;max-width:104% !important;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div 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!important;order : 0;}.fusion-builder-column-0 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-column-0{width:100% !important;order : 0;}.fusion-builder-column-0 > .fusion-column-wrapper {margin-right : 1.92%;margin-left : 1.92%;}}<\/style><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-flex-container.fusion-builder-row-1{ padding-top : 0px;margin-top : 0px;padding-right : 0px;padding-bottom : 0px;margin-bottom : 0px;padding-left : 0px;}<\/style><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-2 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"background-color: #ffffff;background-position: center bottom;background-repeat: repeat-x;border-width: 0px 0px 0px 0px;border-color:rgba(97,158,133,0);border-style:solid;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start\" style=\"max-width:calc( 1170px + 0px );margin-left: calc(-0px \/ 2 );margin-right: calc(-0px \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-1 fusion_builder_column_1_1 1_1 fusion-flex-column fusion-flex-align-self-flex-start fusion-column-no-min-height\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-blend-mode: overlay;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><style type=\"text\/css\">@media only screen and (max-width:1024px) {.fusion-title.fusion-title-1{margin-top:0px!important; margin-right:0px!important;margin-bottom:20px!important;margin-left:0px!important;}}@media only screen and (max-width:640px) {.fusion-title.fusion-title-1{margin-top:0px!important; margin-right:0px!important;margin-bottom:20px!important; margin-left:0px!important;}}<\/style><div class=\"fusion-title title fusion-title-1 fusion-sep-none fusion-title-center fusion-title-text fusion-title-size-one\" style=\"margin-top:0px;margin-right:0px;margin-bottom:20px;margin-left:0px;\"><h1 class=\"title-heading-center fusion-responsive-typography-calculated\" style=\"margin:0;--fontSize:40;line-height:1.4;\"><strong><span style=\"color: #019fba;\">BONE BLAST<\/span><\/strong>, THE TECHNOLOGICAL EVOLUTION THAT MAKES DEVICES <strong><span style=\"color: var(--awb-custom_color_1);\">OSTEOINDUCTIVE<\/span><\/strong><\/h1><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-1{width:100% !important;margin-top : 0px;margin-bottom : 60px;}.fusion-builder-column-1 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 0px;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 0px;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-1{width:100% !important;}.fusion-builder-column-1 > .fusion-column-wrapper {margin-right : 0px;padding-bottom : 60px !important;margin-left : 0px;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-column-1{width:100% !important;}.fusion-builder-column-1 > .fusion-column-wrapper {margin-right : 0px;margin-left : 0px;}}<\/style><\/div><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-2 fusion_builder_column_1_1 1_1 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div class=\"fusion-builder-row fusion-builder-row-inner fusion-row fusion-flex-align-items-flex-start\" style=\"width:calc( 100% + 0px ) !important;max-width:calc( 100% + 0px ) !important;margin-left: calc(-0px \/ 2 );margin-right: calc(-0px \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column_inner fusion-builder-nested-column-0 fusion_builder_column_inner_1_3 1_3 fusion-flex-column fusion-flex-align-self-center\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div class=\" md-text-align-center\"><span class=\" fusion-imageframe imageframe-none imageframe-1 hover-type-none\" style=\"max-width:50vh;\"><img width=\"850\" height=\"506\" title=\"LOGO-BONE-BLAST_trasparente_WEB\" src=\"https:\/\/mtortho.com\/wp-content\/uploads\/2022\/05\/LOGO-BONE-BLAST_trasparente_WEB.png\" data-orig-src=\"https:\/\/mtortho.com\/wp-content\/uploads\/2022\/05\/LOGO-BONE-BLAST_trasparente_WEB.png\" alt class=\"lazyload img-responsive wp-image-1755\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%27850%27%20height%3D%27506%27%20viewBox%3D%270%200%20850%20506%27%3E%3Crect%20width%3D%27850%27%20height%3D%27506%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-srcset=\"https:\/\/mtortho.com\/wp-content\/uploads\/2022\/05\/LOGO-BONE-BLAST_trasparente_WEB-200x119.png 200w, https:\/\/mtortho.com\/wp-content\/uploads\/2022\/05\/LOGO-BONE-BLAST_trasparente_WEB-400x238.png 400w, https:\/\/mtortho.com\/wp-content\/uploads\/2022\/05\/LOGO-BONE-BLAST_trasparente_WEB-600x357.png 600w, https:\/\/mtortho.com\/wp-content\/uploads\/2022\/05\/LOGO-BONE-BLAST_trasparente_WEB-800x476.png 800w, https:\/\/mtortho.com\/wp-content\/uploads\/2022\/05\/LOGO-BONE-BLAST_trasparente_WEB.png 850w\" data-sizes=\"auto\" data-orig-sizes=\"(max-width: 1024px) 100vw, (max-width: 640px) 100vw, 400px\" \/><\/span><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-nested-column-0{width:33.333333333333% !important;margin-top : 0px;margin-bottom : 20px;}.fusion-builder-nested-column-0 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 20px;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 0px;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-nested-column-0{width:100% !important;order : 0;}.fusion-builder-nested-column-0 > .fusion-column-wrapper {margin-right : 0px;margin-left : 0px;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-nested-column-0{width:100% !important;order : 0;}.fusion-builder-nested-column-0 > .fusion-column-wrapper {margin-right : 0px;margin-left : 0px;}}<\/style><\/div><div class=\"fusion-layout-column fusion_builder_column_inner fusion-builder-nested-column-1 fusion_builder_column_inner_1_3 1_3 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div class=\"fusion-text fusion-text-1\"><p>In vitro studies on the genic expression of human cells similar to osteoblasts have shown that the trabecular structure in question is effectively capable of stimulating the proliferation and differentiation of the osteoblasts. It has also been shown that this material (Ti6Al4V) is able to encourage the down-regulation of the numerous genes involved in inflammatory processes and to modulate the genes that govern the immune system.<\/p>\n<\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-nested-column-1{width:33.333333333333% !important;margin-top : 0px;margin-bottom : 20px;}.fusion-builder-nested-column-1 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 20px;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 0px;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-nested-column-1{width:100% !important;order : 0;}.fusion-builder-nested-column-1 > .fusion-column-wrapper {margin-right : 0px;margin-left : 0px;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-nested-column-1{width:100% !important;order : 0;}.fusion-builder-nested-column-1 > .fusion-column-wrapper {margin-right : 0px;margin-left : 0px;}}<\/style><\/div><div class=\"fusion-layout-column fusion_builder_column_inner fusion-builder-nested-column-2 fusion_builder_column_inner_1_3 1_3 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div class=\"fusion-text fusion-text-2\"><p>Adult human adipose tissue-derived stem cells (hASCs) cultivated on a trabecular titanium scaffold were able to join together with the net, proliferate and differentiate in a phenotype similar to an osteoblast, with the subsequent production of a mineralized extracellular matrix. The quality and quantity of the extracellular matrix are of fundamental important in determining the effective osseointegration of a material and as a result, the resistance and survival of a prosthetic implant.<\/p>\n<\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-nested-column-2{width:33.333333333333% !important;margin-top : 0px;margin-bottom : 20px;}.fusion-builder-nested-column-2 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 0px;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 0px;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-nested-column-2{width:100% !important;order : 0;}.fusion-builder-nested-column-2 > .fusion-column-wrapper {margin-right : 0px;margin-left : 0px;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-nested-column-2{width:100% !important;order : 0;}.fusion-builder-nested-column-2 > .fusion-column-wrapper {margin-right : 0px;margin-left : 0px;}}<\/style><\/div><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-2{width:100% !important;margin-top : 0px;margin-bottom : 20px;}.fusion-builder-column-2 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 0px;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 0px;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-2{width:100% !important;order : 0;}.fusion-builder-column-2 > .fusion-column-wrapper {margin-right : 0px;margin-left : 0px;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-column-2{width:100% !important;order : 0;}.fusion-builder-column-2 > .fusion-column-wrapper {margin-right : 0px;margin-left : 0px;}}<\/style><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-flex-container.fusion-builder-row-2{ padding-top : 110px;margin-top : 0px;padding-right : 0px;padding-bottom : 0px;margin-bottom : 0px;padding-left : 0px;}@media only screen and (max-width:1024px) {.fusion-body .fusion-flex-container.fusion-builder-row-2{ padding-top : 80px;}}<\/style><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-3 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"background-color: var(--awb-color1);background-position: center bottom;background-repeat: repeat-x;border-width: 0px 0px 0px 0px;border-color:rgba(97,158,133,0);border-style:solid;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start\" style=\"max-width:calc( 1170px + 0px );margin-left: calc(-0px \/ 2 );margin-right: calc(-0px \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-3 fusion_builder_column_1_1 1_1 fusion-flex-column fusion-flex-align-self-flex-start fusion-column-no-min-height\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-blend-mode: overlay;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><style type=\"text\/css\">@media only screen and (max-width:1024px) {.fusion-title.fusion-title-2{margin-top:0px!important; margin-right:0px!important;margin-bottom:20px!important;margin-left:0px!important;}}@media only screen and (max-width:640px) {.fusion-title.fusion-title-2{margin-top:0px!important; margin-right:0px!important;margin-bottom:20px!important; margin-left:0px!important;}}<\/style><div class=\"fusion-title title fusion-title-2 fusion-sep-none fusion-title-center fusion-title-text fusion-title-size-one\" style=\"margin-top:0px;margin-right:0px;margin-bottom:20px;margin-left:0px;\"><h1 class=\"title-heading-center fusion-responsive-typography-calculated\" style=\"margin:0;--fontSize:40;line-height:1.4;\">SCIENTIFIC <strong style=\"color: var(--awb-custom_color_1);\">EVIDENCE<\/strong><\/h1><\/div><div class=\"fusion-separator\" style=\"align-self: center;margin-left: auto;margin-right: auto;margin-top:30px;margin-bottom:60px;width:100%;max-width:40%;\"><div class=\"fusion-separator-border sep-single\" style=\"border-color:#e0e0e0;border-top-width:1px;\"><\/div><\/div><div class=\"fusion-text fusion-text-3\" style=\"text-align:center;\"><p style=\"text-align: center;\">At the <b>University of Pavia<\/b> in vitro tests were also carried out on a <b>trabecular titanium<\/b> scaffold to assess the osteoinductive properties of the material in contact with biological tissue. Mesenchymal stem cells were extracted from the fatty tissue and cultivated in a controlled environment on a scaffold with a porosity of 650 \u00b5m. At different time intervals, analyses were carried out using an electronic scanning microscope to assess the adhesion and proliferation of the cells cultivated.<\/p>\n<p style=\"text-align: center;\">The cavities of the porous trabecular structure are filled by cell regrowth.<\/p>\n<\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-3{width:100% !important;margin-top : 0px;margin-bottom : 60px;}.fusion-builder-column-3 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 0px;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 0px;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-3{width:100% !important;}.fusion-builder-column-3 > .fusion-column-wrapper {margin-right : 0px;margin-left : 0px;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-column-3{width:100% !important;margin-bottom : 0;}.fusion-builder-column-3 > .fusion-column-wrapper {margin-right : 0px;margin-left : 0px;}}<\/style><\/div><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-4 fusion_builder_column_1_3 1_3 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div style=\"text-align:center;\"><span class=\" fusion-imageframe imageframe-none imageframe-2 hover-type-none\"><img width=\"347\" height=\"259\" title=\"A_stabilit\u00e0\" src=\"https:\/\/mtortho.com\/wp-content\/uploads\/2022\/08\/A_stabilita.png\" data-orig-src=\"https:\/\/mtortho.com\/wp-content\/uploads\/2022\/08\/A_stabilita.png\" alt class=\"lazyload img-responsive wp-image-2309\" 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style=\"text-align:center;\"><span class=\" fusion-imageframe imageframe-none imageframe-4 hover-type-none\"><img width=\"347\" height=\"259\" title=\"C_stabilit\u00e0\" src=\"https:\/\/mtortho.com\/wp-content\/uploads\/2022\/08\/C_stabilita.png\" data-orig-src=\"https:\/\/mtortho.com\/wp-content\/uploads\/2022\/08\/C_stabilita.png\" alt class=\"lazyload img-responsive wp-image-2313\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%27347%27%20height%3D%27259%27%20viewBox%3D%270%200%20347%20259%27%3E%3Crect%20width%3D%27347%27%20height%3D%27259%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-srcset=\"https:\/\/mtortho.com\/wp-content\/uploads\/2022\/08\/C_stabilita-200x149.png 200w, https:\/\/mtortho.com\/wp-content\/uploads\/2022\/08\/C_stabilita.png 347w\" data-sizes=\"auto\" data-orig-sizes=\"(max-width: 1024px) 100vw, (max-width: 640px) 100vw, 347px\" \/><\/span><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-6{width:33.333333333333% !important;margin-top : 0px;margin-bottom : 0px;}.fusion-builder-column-6 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 0;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 0;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-6{width:100% !important;order : 0;}.fusion-builder-column-6 > .fusion-column-wrapper {margin-right : 0px;margin-left : 0px;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-column-6{width:100% !important;order : 0;}.fusion-builder-column-6 > .fusion-column-wrapper {margin-right : 0px;margin-left : 0px;}}<\/style><\/div><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-7 fusion_builder_column_1_1 1_1 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-center fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div class=\"fusion-text fusion-text-4\" style=\"text-align:center;\"><p>Scan using the electronic microscope of the empty cage (A) and the cage in which hASCs were sown and cultivated in a growth medium (B) and an osteogenic medium (C) for 21 days. Magnifications: A:202x. B:205x. C:202x<\/p>\n<\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-7{width:100% !important;margin-top : 5VH;margin-bottom : 20px;}.fusion-builder-column-7 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 0px;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 0px;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-7{width:100% !important;order : 0;}.fusion-builder-column-7 > .fusion-column-wrapper {margin-right : 0px;margin-left : 0px;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-column-7{width:100% !important;order : 0;}.fusion-builder-column-7 > .fusion-column-wrapper {margin-right : 0px;margin-left : 0px;}}<\/style><\/div><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-8 fusion_builder_column_1_1 1_1 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div style=\"text-align:center;\"><span class=\" fusion-imageframe imageframe-none imageframe-5 hover-type-none\"><img width=\"681\" height=\"327\" title=\"Artboard 1\" src=\"https:\/\/mtortho.com\/wp-content\/uploads\/2022\/08\/Artboard-1.png\" data-orig-src=\"https:\/\/mtortho.com\/wp-content\/uploads\/2022\/08\/Artboard-1.png\" alt class=\"lazyload img-responsive wp-image-2319\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%27681%27%20height%3D%27327%27%20viewBox%3D%270%200%20681%20327%27%3E%3Crect%20width%3D%27681%27%20height%3D%27327%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-srcset=\"https:\/\/mtortho.com\/wp-content\/uploads\/2022\/08\/Artboard-1-200x96.png 200w, https:\/\/mtortho.com\/wp-content\/uploads\/2022\/08\/Artboard-1-400x192.png 400w, https:\/\/mtortho.com\/wp-content\/uploads\/2022\/08\/Artboard-1-600x288.png 600w, https:\/\/mtortho.com\/wp-content\/uploads\/2022\/08\/Artboard-1.png 681w\" data-sizes=\"auto\" data-orig-sizes=\"(max-width: 1024px) 100vw, (max-width: 640px) 100vw, 681px\" \/><\/span><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-8{width:100% !important;margin-top : 10%;margin-bottom : 0px;}.fusion-builder-column-8 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0 !important;margin-right : 0px;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 0;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-8{width:100% !important;order : 0;}.fusion-builder-column-8 > .fusion-column-wrapper {margin-right : 0px;margin-left : 0px;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-column-8{width:100% !important;order : 0;}.fusion-builder-column-8 > .fusion-column-wrapper {margin-right : 0px;margin-left : 0px;}}<\/style><\/div><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-9 fusion_builder_column_1_1 1_1 fusion-flex-column\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-center fusion-content-layout-column\" style=\"background-position:left top;background-repeat:no-repeat;-webkit-background-size:cover;-moz-background-size:cover;-o-background-size:cover;background-size:cover;padding: 0px 0px 0px 0px;\"><div class=\"fusion-text fusion-text-5\" style=\"text-align:center;\"><p><span style=\"background-color: var(--awb-color1); color: var(--body_typography-color); font-family: var(--body_typography-font-family); font-size: var(--body_typography-font-size); font-style: var(--body_typography-font-style,normal); font-weight: var(--body_typography-font-weight); letter-spacing: var(--body_typography-letter-spacing);\">An in vitro study was carried out at <\/span><b style=\"background-color: var(--awb-color1); color: var(--body_typography-color); font-family: var(--body_typography-font-family); font-size: var(--body_typography-font-size); font-style: var(--body_typography-font-style,normal); letter-spacing: var(--body_typography-letter-spacing);\">IRCCS Galeazzi Orthopaedic Institute in Milan<\/b><span style=\"background-color: var(--awb-color1); color: var(--body_typography-color); font-family: var(--body_typography-font-family); font-size: var(--body_typography-font-size); font-style: var(--body_typography-font-style,normal); font-weight: var(--body_typography-font-weight); letter-spacing: var(--body_typography-letter-spacing);\"> in which mesenchymal stem cells (MSC) were cultivated isolated from subcutaneous adipose tissue (adipose-MSC, ASC) on a trabecular titanium scaffold made using our EBM technology.<\/span><\/p>\n<p>It was observed that in 21 days, the MSC colonized the entire scaffold and osteogenic markers were detected, such as ALP activity (early) and calcium deposition (late), showing its osteoinductive properties.<span style=\"background-color: var(--awb-color1); color: var(--body_typography-color); font-family: var(--body_typography-font-family); font-size: var(--body_typography-font-size); font-style: var(--body_typography-font-style,normal); font-weight: var(--body_typography-font-weight); letter-spacing: var(--body_typography-letter-spacing);\"><br \/><\/span><\/p>\n<\/div><div class=\"fusion-text fusion-text-6\" style=\"margin-top:10%;\"><p>BIBLIOGRAPHY:<\/p>\n<ul>\n<li>Ragni E, Perucca Orfei C, Bidossi A, De Vecchi E, Francaviglia N, Romano A, Maestretti G, Tartara F, de Girolamo L. Superior Osteo-Inductive and Osteo-Conductive Properties of Trabecular Titanium vs. PEEK Scaffolds on Human Mesenchymal Stem Cells: A Proof of Concept for the Use of Fusion Cages. Int J Mol Sci. 2021 Feb 27;22(5):2379. doi: 10.3390\/ijms22052379. PMID: 33673509; PMCID: PMC7956826.<\/li>\n<li><a href=\"https:\/\/www.nature.com\/articles\/s41598-020-75385-y\">Caliogna, L., Bina, V., Botta, L. et al. Osteogenic potential of human adipose derived stem cells (hASCs) seeded on titanium trabecular spinal cages. Sci Rep 10, 18284 (2020).<\/a><\/li>\n<\/ul>\n<\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-builder-column-9{width:100% !important;margin-top : 5VH;margin-bottom : 20px;}.fusion-builder-column-9 > .fusion-column-wrapper {padding-top : 0px !important;padding-right : 0px !important;margin-right : 0px;padding-bottom : 0px !important;padding-left : 0px !important;margin-left : 0px;}@media only screen and (max-width:1024px) {.fusion-body .fusion-builder-column-9{width:100% !important;order : 0;}.fusion-builder-column-9 > .fusion-column-wrapper {margin-right : 0px;margin-left : 0px;}}@media only screen and (max-width:640px) {.fusion-body .fusion-builder-column-9{width:100% !important;order : 0;}.fusion-builder-column-9 > .fusion-column-wrapper {margin-right : 0px;margin-left : 0px;}}<\/style><\/div><\/div><style type=\"text\/css\">.fusion-body .fusion-flex-container.fusion-builder-row-3{ padding-top : 110px;margin-top : 0px;padding-right : 0px;padding-bottom : 110px;margin-bottom : 0px;padding-left : 0px;}@media only screen and (max-width:1024px) {.fusion-body .fusion-flex-container.fusion-builder-row-3{ padding-top : 80px;}}<\/style><\/div><\/p>\n<script>function getWR360PopupSkin(){return 'light_clean';}<\/script>","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"100-width.php","meta":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v19.5.1 - 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